Zebrafish Nol10 Antibody / Nucleolar protein 10, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-RZ1140
Supplier Catalog Number:
RZ1140
Alternative Catalog Number:
NSJ-RZ1140
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
IHC-P
Species Reactivity:
Zebrafish
Immunogen:
An E.coli-derived zebrafish Nol10 recombinant protein (amino acids Y73-D497) was used as the immunogen for the Zebrafish Nol10 antibody.
By immunoprecipitation of human AATF it was discovered that AATF forms a salt-stable protein complex together with neuroguidin (NGDN) and NOL10 and demonstrated that the AATF-NGDN-NOL10 (ANN) complex functions in ribosome biogenesis. All three ANN complex members localize to nucleoli and display a mutual dependence with respect to protein stability. Mapping of protein-protein interaction domains revealed the importance of both the evolutionary conserved WD40 repeats in NOL10 and the UTP3/SAS10 domain in NGDN for complex formation.
