An E.coli-derived zebrafish Etf1a/b recombinant protein (amino acids D9-K344) was used as the immunogen for the Zebrafish Etf1 antibody.
Eukaryotic translation termination factor 1 (eRF1),also known asTB3-1,is a protein that in humans is encoded by the ETF1 gene. It is mapped to 5q31.2. This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA,UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6,7,and X.
