COL2A1 Antibody / Collagen II, Clone: [COL2A1/8882R], Rabbit, Monoclonal
Biozol Catalog Number:
NSJ-V4276-20UG
Supplier Catalog Number:
V4276-20UG
Alternative Catalog Number:
NSJ-V4276-20UG
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, IHC-P
Species Reactivity:
Human
Immunogen:
Recombinant full-length human COL2A1 protein was used as the immunogen for the COL2A1 antibody.
The extensive family of COL gene products (collagens) is composed of several chain types, including fibril-forming interstitial collagens (types I, II, III and V) and basement membrane collagens (type IV), each type containing multiple isoforms. Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue architecture and function. In cartilage, Collagen Type II constitutes the bulk of the fibril. Sensitization with Collagen Type II induces an erosive polyarthritis in rats, mice and higher primates which can resemble rheumatoid arthritis and relapsing polychrondritis.
