IMP3 Antibody / Insulin like growth factor 2 mRNA binding protein 3, Clone: [IMP3/8934R], Rabbit, Monoclonal
Biozol Catalog Number:
NSJ-V4394-20UG
Supplier Catalog Number:
V4394-20UG
Alternative Catalog Number:
NSJ-V4394-20UG
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
IHC-P
Species Reactivity:
Human
Immunogen:
A recombinant fragment of human protein was used as the immunogen for the IMP3 antibody.
Imp3, also known as BRMS2, C15orf12 or MRPS4, is a 184 amino acid protein that contains one S4 RNA-binding domain and is the mammalian homolog of the yeast Imp3 protein. Localized to the nucleus, Imp3 exists as a component of a heterotrimeric complex consisting of MPP10, Imp3 and Imp4 and, in this complex, plays a key role in early cleavage events during pre-18S ribosomal processing. The gene encoding Imp3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
