Topoisomerase II alpha Antibody / TOP2A, Clone: [TOP2A/8103R], Rabbit, Monoclonal
Biozol Catalog Number:
NSJ-V4495-20UG
Supplier Catalog Number:
V4495-20UG
Alternative Catalog Number:
NSJ-V4495-20UG
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
IHC-P
Species Reactivity:
Human
Immunogen:
A recombinant partial protein sequence (within amino acids 1431-1531) from the human protein was used as the immunogen for the Topoisomerase II alpha antibody.
The topoisomerase II-Alpha isoform is a 170kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-Alpha is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-Alpha is the predominant mechanism of resistance to several chemotherapeutic agents.
