MHC class I related protein 1 Antibody / MR1, Clone: [MR1/7577], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V4756-20UG
Supplier Catalog Number:
V4756-20UG
Alternative Catalog Number:
NSJ-V4756-20UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
IHC-P
Species Reactivity:
Human
Immunogen:
A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the MHC class I related protein 1 antibody.
MR1 (major histocompatibility complex, class I-related), also known as HLALS, is a 341 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum, as well as to the extracellular side of the cell membrane, and contains one Ig-like C1-type domain. Expressed ubiquitously, MR1 exists as a heterodimer with b-2-Microglobulin and plays an important role in antigen presentation, specifically in the development and expansion of mucosalassociated invariant T cells (MAITs). MAITs are located in the gut and are involved in monitoring flora levels, as well as in conveying distress signals to other areas of the body, indicating a role for MR1 in proper digestion and immune system function. MR1 exists as four alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 1.
