p53 Tumor Suppressor Protein Antibody, Clone: [TP53/7002R], Rabbit, Monoclonal
Biozol Catalog Number:
NSJ-V5425SAF-100UG
Supplier Catalog Number:
V5425SAF-100UG
Alternative Catalog Number:
NSJ-V5425SAF-100UG
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
FACS, IHC-P
Species Reactivity:
Human
Immunogen:
Recombinant human full-length TP53 protein was used as the immunogen for the p53 Tumor Suppressor Protein antibody.
p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
