RET Antibody / c-RET, Clone: [RET/8786], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V5443-20UG
Supplier Catalog Number:
V5443-20UG
Alternative Catalog Number:
NSJ-V5443-20UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
IHC-P
Species Reactivity:
Human
Immunogen:
A recombinant fragment (within amino acids 702-848) of human RET protein was used as the immunogen for the RET antibody.
The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system, in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney. Alterations in the RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung s disease.
