Recombinant CgA Antibody / Chromogranin A, Clone: [rCHGA/9612], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V5459-20UG
Supplier Catalog Number:
V5459-20UG
Alternative Catalog Number:
NSJ-V5459-20UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
IHC-P
Species Reactivity:
Human
Immunogen:
Recombinant full-length human Chromogranin A protein was used as the immunogen for the recombinant CgA antibody.
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
