BRCA1 Antibody / Breast Cancer Marker, Clone: [BRCA1/2973], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V5544-100UG
Supplier Catalog Number:
V5544-100UG
Alternative Catalog Number:
NSJ-V5544-100UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
ELISA
Species Reactivity:
Human
Immunogen:
A recombinant fragment (within amino acids 445-620) of human BRCA1 protein was used as the immunogen for the BRCA1 antibody.
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
