STAT3 Antibody / Signal Transducer and Activator of Transcription 3, Clone: [PCRP-STAT3-2F12], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V5546-100UG
Supplier Catalog Number:
V5546-100UG
Alternative Catalog Number:
NSJ-V5546-100UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
ELISA, IHC-P
Species Reactivity:
Human
Immunogen:
Recombinant human full-length STAT3 protein was used as the immunogen for the STAT3 antibody.
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.
