BAP1 Antibody / BRCA1-Associated Protein 1, Clone: [BAP1/9795R], Rabbit, Monoclonal
Biozol Catalog Number:
NSJ-V5815-100UG
Supplier Catalog Number:
V5815-100UG
Alternative Catalog Number:
NSJ-V5815-100UG
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
IHC-P
Species Reactivity:
Human
Immunogen:
A portion of amino acids 400-729 from human BRCA1-Associated Protein 1 protein was used as the immunogen for the BAP1 antibody.
The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.
