Purified human IGF1 protein was used as the immunogen for this IGF-1 antibody.
This antibody is specific to Insulin-like Growth Factor (IGF1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.
The optimal dilution of the IGF-1 antibody for each application should be determined by the researcher. 1. Required HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
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