QKI Antibody / Protein Quaking, Clone: [PCRP-QKI-2F10], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V9749SAF-100UG
Supplier Catalog Number:
V9749SAF-100UG
Alternative Catalog Number:
NSJ-V9749SAF-100UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
ELISA, FACS, IF, WB
Species Reactivity:
Human
Immunogen:
Recombinant full-length human protein was used as the immunogen for the QKI antibody.
QKI, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5. Additionally, QKI regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events.
