AKR1C1 facilitates the interaction of STAT3 and JAK2 in NSCLC. (A)AKR1C1/2/3 possessed no kinase activity. Purified proteins including His-JAK2, GST-AKR1C1, GST-AKR1C2, GST-AKR1C3 with GST-STAT3 were subjected toin vitrokinase assay, and the phosphorylation level of STAT3 was examined.Figure 6. PMID: 29344298.
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