WM1963 is a human melanoma cell line that displays a melanocytic morphology and was established from a tissue sample of a 56-year-old male patient. This cell line contains a N581S mutation in BRAF gene resulting in an amino acid substitution from asparagine to serine at codon 581 (Asn581Ser) and A146T mutation in N-RAS gene resulting in a substitution of alanine with threonine at codon 146 (Ala146Thr). WM1963 cells produce xenograft tumors when injected into immunocompromised mice.
Concentration:
1.0 million cells/mL (Count By Hemocytometer)
Buffer:
None
Source:
Human
Form:
Frozen Cell Suspension
Application Notes:
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Human melanoma tumor cells with known gene mutations, disease stage, STR, and RPPA profiling
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