Non-viable cell pellet was generated from cell line WM239A. WM239A is a metastatic human melanoma cell line with thin elongated fibroblastic morphology. This cell line was derived from the same patient as the cell lines WM115, WM266-4, and WM165-1. WM115 cell line originated from the primary tumor, and WM239A, WM165-1 and WM266-4 were from individual lymph-node metastases. The subject (55-year-old female) displayed VGP with a Clark level III tumor with thickness of 2.24mm.This cell line features the specific V600D (Val600Asp) mutation at codon 600 in the BRAF gene. This cell line also expresses PTEN loss of function including hemizygous deletion. WM239A cell line is wild type for N-RAS, c-KIT, and CDK4 genes. WM239A cells produce xenograft tumors when injected into immunocompromised mice.
Concentration:
5.0 million cells (Count By Hemocytometer)
Buffer:
None
Source:
Human
Form:
Frozen Cell Pellet
Application Notes:
Frozen non-viable cell pellets can be used for in vitro experiments such as Western blotting and other immunoassays, genomic DNA isolation, STR profiling, and RNA isolation.
Human melanoma tumor cell pellets for assessment of proteins and their phosphorylation status
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