WM3928 is a human metastatic melanoma cell line that displays a mesenchymal morphology. This cell line was established from a left inguinal lymph node metastatic site of a patient. This cell line contains the PTEN Y177X substitution mutation. Y177 is a phosphorylation site in PTEN and mutation of Y177 leads to misregulation of PTEN function. This cell line contains wild type BRAF, N-RAS, c-KIT and CDK4 genes. WM3928 cells produce xenograft tumors when injected into immunocompromised mice.
Concentration:
1.0 million cells/mL (Count By Hemocytometer)
Buffer:
None
Source:
Human
Form:
Frozen Cell Suspension
Application Notes:
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Human melanoma tumor cells with known gene mutations, disease stage, STR, and RPPA profiling
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