1-Phenylbiguanide HCl, as 5-HT3 receptor agonists(3-100 µM, pEC50 5.050.06), acutely increased XII (hypoglossal) burst frequency and regularity, and decreased bursts/episode . 1-Phenylbiguanide HCl produced a dose-related (10-500 microM) increase in the release of dopamine (280-2000%). When nomifensine (5 microM) was included in the Ringer solution, the effect of 1-Phenylbiguanide HCl on the release of dopamine was ameliorated or inhibited.
Molecular Weight:
213.67
Purity:
0.9931
CAS Number:
[55-57-2]
Formula:
C8H12ClN5
Target:
Others|||5-HT Receptor
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