Colchicine is an orally active natural alkaloid that acts by inhibiting microtubule polymerization (IC50 = 3 nM) and as a competitive antagonist of the alpha3 glycine receptor. It possesses broad anti-inflammatory, immunosuppressive, and antifibrotic activities, can inhibit NLRP3 inflammasome activation to prevent NSAID-induced small intestine injury, holds potential for gouty arthritis and rheumatoid arthritis research, and is commonly used to establish Alzheimers disease models.
Molecular Weight:
399.44
Purity:
0.9996
CAS Number:
[64-86-8]
Formula:
C22H25NO6
Target:
Autophagy|||Apoptosis|||Microtubule Associated
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