Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway, this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.
Molecular Weight:
356.41
Purity:
0.9949
CAS Number:
[38194-50-2]
Formula:
C20H17FO3S
Target:
NF-kappaB|||PD-1/PD-L1|||Autophagy|||COX
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