CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.
Molecular Weight:
255.23
CAS Number:
[787504-88-5]
Formula:
C10H13N3O5
Target:
Androgen Receptor|||Apoptosis|||Others
T10896
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