DB1976 is a selenophene analog of DB270 and a highly potent, cell-permeable, fully efficacious transcription factor PU.1 inhibitor. It effectively inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-lambdaB affinity, KD of 12 nM) in vitro. Additionally, DB1976 has an apoptosis-inducing effect.
Molecular Weight:
447.35
Purity:
0.9894
CAS Number:
[1557397-51-9]
Formula:
C20H16N8Se
Target:
Apoptosis
T10964
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