GNE-0439 is a novel, Nav1.7-selective inhibitor with an IC50 of 0.34 uM that also inhibits Nav1.5 (IC50=38.3 uM) and mutant N1742K channels (IC50=0.37 uM), possessing a carboxylic acid group that binds outside the channel pore, distinguishing it from known selective VSD4 binders and making it a valuable tool for ion channel research.
Molecular Weight:
345.48
Purity:
99.60%
CAS Number:
[1241902-40-8]
Formula:
C21H31NO3
Target:
Sodium Channel
T11437
T11437
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