GSK1059865 is a highly selective orexin-1 receptor antagonist that significantly reduces voluntary ethanol intake in ethanol-dependent mice following chronic intermittent ethanol exposure, producing dose-dependent suppression of alcohol consumption without affecting sucrose intake, while exhibiting minimal effects in non-dependent controls except at high doses, thereby highlighting its utility for investigating orexin signaling in alcohol dependence and addictive behaviors.
Molecular Weight:
436.32
CAS Number:
[1191044-58-2]
Formula:
C20H23BrFN3O2
Target:
OX Receptor
T11477
T11477
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