GW274150 is an orally active, selective and potent dual inhibitor of NADPH-dependent human nitric oxide synthase (iNOS) (Kd=40 nM) and rat inducible nitric oxide synthase (iNOS).GW274150 has a low activity against endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) in humans and rats. GW274150 showed protective effects in an inflammatory model of acute lung injury.
Molecular Weight:
219.3
Purity:
96.43%
CAS Number:
[210354-22-6]
Formula:
C8H17N3O2S
Target:
NO Synthase|||NOS
T11518L
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