HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.
Molecular Weight:
574.05
Purity:
99.91%
CAS Number:
[848133-17-5]
Formula:
C31H29ClFN5O3
Target:
EGFR
T11569
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