JHU395 is an orally-bioavailable prodrug of a lipophilic glutamine antagonist (GA), 6-diazo-5-oxo-L-norleucine (DON). It demonstrates delivery of DON to malignant peripheral nerve sheath tumor (MPNST) both in vitro and in vivo, resulting in significant antitumor activity in MPNST. Additionally, JHU395 exhibits plasma stability.
Molecular Weight:
447.48
Purity:
99.15%
CAS Number:
[2079938-92-2]
Formula:
C22H29N3O7
Target:
Apoptosis|||Others
T11717
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