Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines.
Molecular Weight:
428.29
Purity:
99.86%
CAS Number:
[1642300-52-4]
Formula:
C17H10F6N6O
Target:
Others|||CRM1
T11766L
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