ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively).ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN).
Molecular Weight:
369.33
Purity:
99.45%
CAS Number:
[1346233-68-8]
Formula:
C19H26Cl2N2O
Target:
Calcium Channel
T12076L
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