NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.
Molecular Weight:
449.4
Purity:
0.9972
CAS Number:
[1262857-73-7]
Formula:
C21H19F4N5O2
Target:
BACE|||Beta-Secretase
T12188
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