trans-Ned 19, CAS [[1354235-96-3]]

Product Overview

• Article Name: trans-Ned 19, CAS [[1354235-96-3]]
• Biozol Catalog Number: TGM-T12205L
• Supplier Catalog Number: T12205L
• Alternative Catalog Number: TGM-T12205L-1MLX10MM(INDMSO),TGM-T12205L-1MG,TGM-T12205L-5MG,TGM-T12205L-10MG,TGM-T12205L-25MG,TGM-T12205L-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

trans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist and two-pore channel (TPC) blocker. It binds with high affinity to the NAADP receptor to inhibit NAADP-dependent lysosomal/endolysosomal calcium release without affecting IP3 or cADPR-mediated calcium signaling pathways. Functionally, trans-Ned 19 inhibits glucose-induced calcium oscillations in pancreatic islets and low histamine concentration-induced endothelium-dependent vasodilation, and reduces Ebola virus infection of host cells. In immunomodulation, NAADP signaling blockade by trans-Ned 19 promotes the conversion of mouse Th17 cells to regulatory T cells (Tregs) and shows protective effects in intestinal inflammation models.

Product Properties

• Molecular Weight: 514.59
• Purity: 99.87%
• CAS Number: [1354235-96-3]
• Formula: C30H31FN4O3
• Target: Calcium Channel

Images

T12205L

T12205L