PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2.
Molecular Weight:
536.05
Purity:
99.90%
CAS Number:
[1469284-79-4]
Formula:
C23H30ClN7O4S
Target:
Acyltransferase|||Transferase
T12425
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