PIM447 (LGH447) is an oral, selective pan-PIM kinase inhibitor with antitumor and bone-protective effects. It inhibits PIM1, PIM2, and PIM3, induces apoptosis, and decreases the viability, proliferation, and motility of HuH6 and COA67 cells. PIM447 suppresses tumorigenesis in hepatocellular carcinoma and can be used in the study of multiple myeloma.
Molecular Weight:
440.46
Purity:
98.97%
CAS Number:
[1210608-43-7]
Formula:
C24H23F3N4O
Target:
Pim|||Apoptosis
T12475
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