PT2399 is a potent, selective, orally available HIF-2alpha antagonist that directly binds to the PAS B domain of HIF-2alpha (IC50 = 6 nM). PT2399 exhibits antitumor activity. PT2399 specifically blocks the heterodimerization of HIF-2alpha and HIF-1beta, thereby inhibiting the expression of downstream target genes such as VEGF and GLUT1, and exerts its antitumor effects.
Molecular Weight:
419.32
Purity:
98.80%
CAS Number:
[1672662-14-4]
Formula:
C17H10F5NO4S
Target:
HIF/HIF Prolyl-Hydroxylase|||HIF
T12675L
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