T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6167923 impedes NF-kappaB driven Staphylococcus enterotoxin AP (SEAP) activity and boasts improved anti-inflammatory effects, with IC50s values of 2.7 µM for IFN-gamma, 2.9 µM for IL-1beta, and 2.66 µM each for IL-6 and TNF-alpha, demonstrating its efficacy across multiple inflammatory mediators [1].
Molecular Weight:
458.39
Purity:
0.9928
CAS Number:
[2437475-16-4]
Formula:
C17H20BrN3O3S2
Target:
MyD88
T13063
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