(R)-BAY1238097 represents the R-isomer of BAY1238097, which exhibits relatively lower activity compared to its counterpart. BAY1238097 is a highly potent and selective inhibitor targeting the binding of BET proteins to histones, demonstrating significant anti-proliferative effects in various acute myeloid leukemia (AML) and multiple myeloma (MM) models. The high activity is achieved through the down-regulation of c-Myc levels and the subsequent modulation of its downstream transcriptome.
Molecular Weight:
451.56
Purity:
98.77%
CAS Number:
[1564269-85-7]
Formula:
C25H33N5O3
Target:
Epigenetic Reader Domain
T13442
T13442
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