JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.
Molecular Weight:
920.161
CAS Number:
[2209085-22-1]
Formula:
C53H69N5O9
Target:
EGFR|||CDK|||PROTACs
T13743
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