PSI-7409 tetrasodium is the pharmacologically active 5'-triphosphate metabolite of sofosbuvir (PSI-7977) that directly inhibits hepatitis C virus NS5B RNA-dependent RNA polymerase, with IC50 values of 1.6, 2.8, 0.7, and 2.6 µM against GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively, PSI-7409 tetrasodium is widely used to study antiviral mechanisms and genotype-specific polymerase inhibition.
Molecular Weight:
588.09
Purity:
99.97%
CAS Number:
[1621884-22-7]
Formula:
C10H12FN2Na4O14P3
Target:
HCV Protease
T13852
T13852
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