BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 µM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 µM. Its interaction with BDK induces helix movements in the N-terminal domain, leading to BDKs dissociation from the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC).
Molecular Weight:
247.1
Purity:
99.27%
CAS Number:
[34576-94-8]
Formula:
C9H4Cl2O2S
Target:
Bcl-2 Family
T14834
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