Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
Molecular Weight:
257.76
Purity:
85.01%
CAS Number:
[366-70-1]
Formula:
C12H19N3OHCl
Target:
DNA/RNA Synthesis|||DNA Alkylator/Crosslinker
T1488
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