Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is an ATP-competitive pan-class I PI3K inhibitor, with IC50 values of 0.5 nM for PI3Kalpha, 0.7 nM for PI3Kdelta, 3.7 nM for PI3Kbeta, and 6.4 nM for PI3Kgamma. It exhibits superior antitumor activity and demonstrates more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR.
Molecular Weight:
553.44
Purity:
98.80%
CAS Number:
[1402152-13-9]
Formula:
C23H30Cl2N8O4
Target:
mTOR|||Apoptosis|||PI3K
T14998
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