Edicotinib (JNJ-527) is a blood-brain-penetrating, orally active, selective CSF-1R inhibitor (IC50 value is 3.2 nM), with less inhibitory effects on KIT (IC50 value is 20 nM) and FLT3 (IC50 value is 190 nM). Edicotinib (JNJ-527) can block microglial proliferation and attenuate neurodegeneration, and can be used to study Alzheimers disease and rheumatoid arthritis.
Molecular Weight:
461.6
Purity:
98.58%
CAS Number:
[1142363-52-7]
Formula:
C27H35N5O2
Target:
CSF-1R|||c-Fms|||FLT|||c-Kit
T15199
* VAT and and shipping costs not included. Errors and price changes excepted
