GNE-0946 is an effective and selective RORgamma/RORc/NR1F3 antagonist (inverse agonist) with an EC50 of 4 nM in HEK-293 cells. It inhibits IL-17 production in human PBMC cells (IC50 = 17 nM) and can be used in autoimmune disease research.
Molecular Weight:
460.79
Purity:
98.11%
CAS Number:
[1677667-24-1]
Formula:
C22H12ClF3N2O4
Target:
ROR
T15398
T15398
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