JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-beta kinase (IC50=4.2 nM) and PDGFR-alpha kinase (IC50=45 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent.
Molecular Weight:
325.34
Purity:
0.9851
CAS Number:
[627518-40-5]
Formula:
C18H16FN3O2
Target:
PDGFR
T15616
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