KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing, which potently inhibits TNF-alpha production.
Molecular Weight:
460.52
CAS Number:
[1215192-68-9]
Formula:
C24H30F2N4O3
Target:
Prostaglandin Receptor
T15642
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