MRT199665 is an effective and ATP-competitive, selective MARK/SIK/AMPK inhibitor (IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKalpha1/AMPKalpha2, and SIK1/SIK2/SIK3, respectively). MRT199665 suppresses the phosphorylation of SIK substrate CRTC3 at S370. MRT199665 induces apoptosis in MEF2C-activated human acute myeloid leukemia (AML) cells.
Molecular Weight:
469.58
CAS Number:
[1456858-57-3]
Formula:
C28H31N5O2
Target:
Others|||Apoptosis|||AMPK|||SIK
T16142
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