Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-kappaB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-kappaB. Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica L).
Molecular Weight:
466.52
Purity:
95.84%
CAS Number:
[25990-37-8]
Formula:
C27H30O7
Target:
CDK|||Wnt/beta-catenin|||Apoptosis|||NF-kappaB
T16324
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