O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.
Molecular Weight:
432.88
Purity:
97.17%
CAS Number:
[847949-49-9]
Formula:
C21H22ClFN4O3
Target:
EGFR
T16369
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