PF-915275 is an effective and selective inhibitor of human 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1, Ki = 2.3 nM, EC50 = 15 nM in vitro HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.
Molecular Weight:
350.39
Purity:
97.69%
CAS Number:
[857290-04-1]
Formula:
C18H14N4O2S
Target:
Dehydrogenase|||Others
T16510
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